Title : Blockade of ataxia telangiectasia mutated sensitizes hepatoma cell lines to sorafenib by interfering with Akt signaling.

Pub. Date : 2012 Jun 1

PMID : 22265862






1 Functional Relationships(s)
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1 When hepatoma cell lines HepG2 and PLC/PRF/5 were treated with sorafenib plus ATM small inhibitory RNAs, ATM inhibitor KU55933 or caffeine, Akt signaling was suppressed and the cytotoxic effects were significantly potentiated. Caffeine AKT serine/threonine kinase 1 Homo sapiens