Pub. Date : 2012 Aug
PMID : 22261591
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PKI-587 and sorafenib targeting PI3K/AKT/mTOR and Ras/Raf/MAPK pathways synergistically inhibit HCC cell proliferation. | Sorafenib | zinc fingers and homeoboxes 2 | Homo sapiens |
| 2 | EGF increased phosphorylation of Ras/Raf downstream signaling proteins MEK and ERK; EGF-stimulated activation was inhibited by sorafenib. | Sorafenib | zinc fingers and homeoboxes 2 | Homo sapiens |
| 3 | However, when PKI-587 and sorafenib were used in combination, they inhibited all the tested kinases in the Ras/Raf /MAPK and PI3K/AKT/mTOR pathways. | Sorafenib | zinc fingers and homeoboxes 2 | Homo sapiens |
| 4 | CONCLUSION: The combination of PKI-587 and sorafenib has the advantage over monodrug therapy on inhibition of HCC cell proliferation by blocking both PI3K/AKT/mTOR and Ras/Raf/MAPK signaling pathways. | Sorafenib | zinc fingers and homeoboxes 2 | Homo sapiens |