Title : PKI-587 and sorafenib targeting PI3K/AKT/mTOR and Ras/Raf/MAPK pathways synergistically inhibit HCC cell proliferation.

Pub. Date : 2012 Aug

PMID : 22261591






3 Functional Relationships(s)
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1 This study aimed to test the inhibitory effects of PKI-587 and sorafenib as single agents or in combination on HCC (Huh7 cell line) proliferation. Sorafenib MIR7-3 host gene Homo sapiens
2 Combination of PKI-587 and sorafenib was a more effective inhibitor of Huh7 proliferation than the combination of PI-103 and sorafenib. Sorafenib MIR7-3 host gene Homo sapiens
3 Combination of PKI-587 and sorafenib synergistically inhibited epidermal growth factor (EGF)-stimulated Huh7 proliferation compared with monodrug therapy. Sorafenib MIR7-3 host gene Homo sapiens