Pub. Date : 2012 Apr
PMID : 22259019
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | With recombinant UGT enzymes, lorcaserin N-carbamoyl glucuronidation was predominantly catalyzed by three UGT2Bs (UGT2B7, UGT2B15, and UGT2B17), whereas two UGT1As (UGT1A6 and UGT1A9) played a minor role. | lorcaserin | UDP glucuronosyltransferase family 2 member B15 | Homo sapiens |
| 2 | The rank order of catalytic efficiency of human UGT enzymes for lorcaserin N-carbamoyl glucuronidation was UGT2B15 > UGT2B7 > UGT2B17 > UGT1A9 > UGT1A6. | lorcaserin | UDP glucuronosyltransferase family 2 member B15 | Homo sapiens |
| 3 | Inhibition of lorcaserin N-carbamoyl glucuronidation activities of UGT2B7, UGT2B15, and UGT2B17 in human liver microsomes by mefenamic acid, bisphenol A, and eugenol further substantiated the involvement of these UGT2B isoforms. | lorcaserin | UDP glucuronosyltransferase family 2 member B15 | Homo sapiens |