Title : Hydrogen-bond network and pH sensitivity in transthyretin: Neutron crystal structure of human transthyretin.

Pub. Date : 2012 Feb

PMID : 22248451






1 Functional Relationships(s)
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1 This hydrogen-bond network is composed of Thr75, Trp79, His88, Ser112, Pro113, Thr118-B and four water molecules, and is involved in both monomer-monomer and dimer-dimer interactions, suggesting that the double protonation of His88 by acidification breaks the hydrogen-bond network and causes the destabilization of the TTR tetramer. Water transthyretin Homo sapiens