Pub. Date : 2012 Feb
PMID : 22248451
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | This hydrogen-bond network is composed of Thr75, Trp79, His88, Ser112, Pro113, Thr118-B and four water molecules, and is involved in both monomer-monomer and dimer-dimer interactions, suggesting that the double protonation of His88 by acidification breaks the hydrogen-bond network and causes the destabilization of the TTR tetramer. | Water | transthyretin | Homo sapiens |