Title : Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin.

Pub. Date : 2012 Jan 17

PMID : 22247290






1 Functional Relationships(s)
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1 We have now overexpressed every enzyme of the mevalonate pathway to ERG20 in S. cerevisiae CEN.PK2, and compared production to CEN.PK2 engineered identically to the previously engineered S288C strain. Glutaryl-7-aca bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase Saccharomyces cerevisiae S288C