Title : Phosphoinositide 3-kinase/AKT/mTORC1/2 signaling determines sensitivity of Burkitt's lymphoma cells to BH3 mimetics.

Pub. Date : 2012 Mar

PMID : 22241218






1 Functional Relationships(s)
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1 Furthermore, blocking c-MYC function using the inhibitor 10058-F4 also induced apoptosis synergistically with ABT-737, suggesting that maintenance of expression of BCL-2 family members and/or c-MYC by the PI3K/AKT/mTOR pathway could contribute to BL cell survival and resistance to ABT-737. 5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one AKT serine/threonine kinase 1 Homo sapiens