Pub. Date : 2012 Mar 16
PMID : 22232560
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A selection of compounds showing good in silico docking scores into the predicted pockets was retained for testing their in vitro effect on VWF-GPIbalpha complex formation, by which we identified a compound that surprisingly stimulated the VWF-GPIbalpha binding in a ristocetin cofactor ELISA and increased platelet adhesion in whole blood to collagen under arterial shear rate but in contrast inhibited ristocetin-induced platelet aggregation. | Ristocetin | glycoprotein Ib platelet subunit alpha | Homo sapiens |
| 2 | A selection of compounds showing good in silico docking scores into the predicted pockets was retained for testing their in vitro effect on VWF-GPIbalpha complex formation, by which we identified a compound that surprisingly stimulated the VWF-GPIbalpha binding in a ristocetin cofactor ELISA and increased platelet adhesion in whole blood to collagen under arterial shear rate but in contrast inhibited ristocetin-induced platelet aggregation. | Ristocetin | glycoprotein Ib platelet subunit alpha | Homo sapiens |
| 3 | A selection of compounds showing good in silico docking scores into the predicted pockets was retained for testing their in vitro effect on VWF-GPIbalpha complex formation, by which we identified a compound that surprisingly stimulated the VWF-GPIbalpha binding in a ristocetin cofactor ELISA and increased platelet adhesion in whole blood to collagen under arterial shear rate but in contrast inhibited ristocetin-induced platelet aggregation. | Ristocetin | glycoprotein Ib platelet subunit alpha | Homo sapiens |
| 4 | A selection of compounds showing good in silico docking scores into the predicted pockets was retained for testing their in vitro effect on VWF-GPIbalpha complex formation, by which we identified a compound that surprisingly stimulated the VWF-GPIbalpha binding in a ristocetin cofactor ELISA and increased platelet adhesion in whole blood to collagen under arterial shear rate but in contrast inhibited ristocetin-induced platelet aggregation. | Ristocetin | glycoprotein Ib platelet subunit alpha | Homo sapiens |