Title : Essential role of the donor acyl carrier protein in stereoselective chain translocation to a fully reducing module of the nanchangmycin polyketide synthase.

Pub. Date : 2012 Jan 31

PMID : 22229794






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Covalent tethering of the 2-methyl-3-ketobutyryl thioester substrate to the NANS ACP1 domain derived from the natural upstream PKS module of the nanchangmycin synthase significantly enhanced both the stereospecificity and the kinetic efficiency of the sequential polyketide chain translocation and condensation reactions catalyzed by the ketosynthase domain of NANS module 2. Polyketides acid phosphatase 1 Homo sapiens