Title : Coffee polyphenol caffeic acid but not chlorogenic acid increases 5'AMP-activated protein kinase and insulin-independent glucose transport in rat skeletal muscle.

Pub. Date : 2012 Nov

PMID : 22227267






3 Functional Relationships(s)
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1 We explored whether chlorogenic acid and its metabolite, caffeic acid, act directly on skeletal muscle to stimulate 5"-adenosine monophosphate-activated protein kinase (AMPK). caffeic acid protein kinase AMP-activated catalytic subunit alpha 1 Rattus norvegicus
2 Incubation of rat epitrochlearis muscles with Krebs buffer containing caffeic acid (>=0.1 mM, >=30 min) but not chlorogenic acid increased the phosphorylation of AMPKalpha Thr(172), an essential step for kinase activation, and acetyl CoA carboxylase Ser(79), a downstream target of AMPK, in a dose- and time-dependent manner. caffeic acid protein kinase AMP-activated catalytic subunit alpha 1 Rattus norvegicus
3 These results suggest that caffeic acid but not chlorogenic acid acutely stimulates skeletal muscle AMPK activity and insulin-independent glucose transport with a reduction of the intracellular energy status. caffeic acid protein kinase AMP-activated catalytic subunit alpha 1 Rattus norvegicus