Pub. Date : 2012 Jan 1
PMID : 22215907
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Investigators established Hsp90"s druggability using the natural products geldanamycin and radicicol, which mimic the unusual ATP structure adopted in the chaperone"s N-terminal nucleotide-binding pocket and cause potent and selective blockade of ATP binding/hydrolysis, inhibit chaperone function, deplete oncogenic clients, and show antitumor activity. | monorden | heat shock protein 90 alpha family class A member 1 | Homo sapiens |