Title : Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development.

Pub. Date : 2012 Jan 27

PMID : 22206904






2 Functional Relationships(s)
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1 We found that interleukin-15 (IL-15), a cytokine critical for CD8(+) memory T cells, regulated SRC and oxidative metabolism by promoting mitochondrial biogenesis and expression of carnitine palmitoyl transferase (CPT1a), a metabolic enzyme that controls the rate-limiting step to mitochondrial fatty acid oxidation (FAO). Fatty Acids interleukin 15 Homo sapiens
2 We found that interleukin-15 (IL-15), a cytokine critical for CD8(+) memory T cells, regulated SRC and oxidative metabolism by promoting mitochondrial biogenesis and expression of carnitine palmitoyl transferase (CPT1a), a metabolic enzyme that controls the rate-limiting step to mitochondrial fatty acid oxidation (FAO). Fatty Acids interleukin 15 Homo sapiens