Pub. Date : 2012 Jan 10
PMID : 22203986
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | D-amino acid oxidase controls motoneuron degeneration through D-serine. | Serine | D-amino acid oxidase | Mus musculus |
| 2 | More recently, a unique mutation in the D-amino acid oxidase (DAO) gene, encoding a D-serine degrading enzyme, was reported to be associated with classical familial ALS. | Serine | D-amino acid oxidase | Mus musculus |
| 3 | More recently, a unique mutation in the D-amino acid oxidase (DAO) gene, encoding a D-serine degrading enzyme, was reported to be associated with classical familial ALS. | Serine | D-amino acid oxidase | Mus musculus |
| 4 | Here, we show that genetic inactivation of DAO in mice reduces the number and size of lower motoneurons with axonal degeneration, and that suppressed DAO activity in reactive astrocytes in the reticulospinal tract, one of the major inputs to the lower motoneurons, predominantly contributes to the D-serine increase in the mSOD1 mouse. | Serine | D-amino acid oxidase | Mus musculus |
| 5 | Here, we show that genetic inactivation of DAO in mice reduces the number and size of lower motoneurons with axonal degeneration, and that suppressed DAO activity in reactive astrocytes in the reticulospinal tract, one of the major inputs to the lower motoneurons, predominantly contributes to the D-serine increase in the mSOD1 mouse. | Serine | D-amino acid oxidase | Mus musculus |
| 6 | Our findings provide evidence that DAO has a pivotal role in motoneuron degeneration through D-serine regulation and that inactivity of DAO is a common feature between the mSOD1 ALS mouse model and the mutant DAO-associated familial ALS. | Serine | D-amino acid oxidase | Mus musculus |