Pub. Date : 2012 Mar
PMID : 22200683
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Celecoxib suppresses fibroblast proliferation and collagen expression by inhibiting ERK1/2 and SMAD2/3 phosphorylation. | Celecoxib | SMAD family member 2 | Homo sapiens |
| 2 | This study aimed to investigate whether celecoxib suppresses fibroblast proliferation and collagen expression by inhibiting extracellular signal-regulated kinase 1/2 (ERK1/2) and SMAD2/3 phosphorylation. | Celecoxib | SMAD family member 2 | Homo sapiens |
| 3 | Celecoxib also suppressed collagen expression (0.35-fold COL3 and 0.43-fold COL1 with 320 micromol/l celecoxib relative to the untreated group following stimulation for 3 h, p<0.01) when stimulated by TGF-beta1, by inhibiting SMAD2/3 phosphorylation but not SMAD2/3 expression. | Celecoxib | SMAD family member 2 | Homo sapiens |
| 4 | Celecoxib also suppressed collagen expression (0.35-fold COL3 and 0.43-fold COL1 with 320 micromol/l celecoxib relative to the untreated group following stimulation for 3 h, p<0.01) when stimulated by TGF-beta1, by inhibiting SMAD2/3 phosphorylation but not SMAD2/3 expression. | Celecoxib | SMAD family member 2 | Homo sapiens |
| 5 | Celecoxib is capable of inhibiting ERK1/2 and SMAD2/3 phosphorylation, which is responsible for NIH/3T3 fibroblast proliferation and collagen expression. | Celecoxib | SMAD family member 2 | Homo sapiens |