Pub. Date : 2012 Oct
PMID : 22197621
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BRCA-1 promoter hypermethylation and silencing induced by the aromatic hydrocarbon receptor-ligand TCDD are prevented by resveratrol in MCF-7 cells. | Resveratrol | BRCA1 DNA repair associated | Homo sapiens |
| 2 | Conversely, the phytoalexin resveratrol, selected as a prototype dietary AhR antagonist, antagonized at physiologically relevant doses (1 mumol/L) the TCDD-induced repression of BRCA-1 protein, BRCA-1 promoter methylation and the recruitment of the AhR, MBD2, H3K9me3 and DNMTs (1, 3a and 3b). | Resveratrol | BRCA1 DNA repair associated | Homo sapiens |
| 3 | Conversely, the phytoalexin resveratrol, selected as a prototype dietary AhR antagonist, antagonized at physiologically relevant doses (1 mumol/L) the TCDD-induced repression of BRCA-1 protein, BRCA-1 promoter methylation and the recruitment of the AhR, MBD2, H3K9me3 and DNMTs (1, 3a and 3b). | Resveratrol | BRCA1 DNA repair associated | Homo sapiens |