Pub. Date : 2012 Mar
PMID : 22189830
8 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | Characterization of an alternative low energy fold for bovine alpha-lactalbumin formed by disulfide bond shuffling. | Disulfides | lactalbumin alpha | Bos taurus | ||
| 2 | Bovine alpha-lactalbumin (alphaLA) forms a misfolded disulfide bond shuffled isomer, X-alphaLA. | Disulfides | lactalbumin alpha | Bos taurus | ||
| 3 | Bovine alpha-lactalbumin (alphaLA) forms a misfolded disulfide bond shuffled isomer, X-alphaLA. | Disulfides | lactalbumin alpha | Bos taurus | ||
| 4 | Bovine alpha-lactalbumin (alphaLA) forms a misfolded disulfide bond shuffled isomer, X-alphaLA. | Disulfides | lactalbumin alpha | Bos taurus | ||
| 5 | This X-alphaLA isomer contains two native disulfide bridges (Cys 6-Cys 120 and Cys 28-Cys 111) and two non-native disulfide bridges (Cys 61-Cys 73 and Cys 77-Cys 91). | Disulfides | lactalbumin alpha | Bos taurus | ||
| 6 | This X-alphaLA isomer contains two native disulfide bridges (Cys 6-Cys 120 and Cys 28-Cys 111) and two non-native disulfide bridges (Cys 61-Cys 73 and Cys 77-Cys 91). | Disulfides | lactalbumin alpha | Bos taurus | ||
| 7 | MD simulations have been used to characterize the X-alphaLA isomer and its formation via disulfide bond shuffling and to compare it with the native fold of alphaLA. | Disulfides | lactalbumin alpha | Bos taurus | ||
| 8 | Calcium binding to native alphaLA is shown to help preserve the structure of the beta-domain of the protein limiting possibilities for disulfide bond shuffling. | Disulfides | lactalbumin alpha | Bos taurus | ||