Pub. Date : 2012 May
PMID : 22186670
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of mGluR5 is both sufficient and necessary to drive the nitrative stress because direct activation using the mGluR5-specific agonist (RS)-2-chloro-5-hydroxyphenylglycine also increased iNOS expression and 3-NT formation while knockdown of mGluR5 receptor expression by short hairpin RNA (shRNA) blocked their increase in response to Hcy. | 3-nitrotyrosine | nitric oxide synthase 2, inducible | Mus musculus |
| 2 | Nitric oxide derived from iNOS was required for Hcy-mediated formation of 3-NT because the effect was blocked by 1400W. | 3-nitrotyrosine | nitric oxide synthase 2, inducible | Mus musculus |