Title : Electrophilic PPARĪ³ ligands inhibit corneal fibroblast to myofibroblast differentiation in vitro: a potentially novel therapy for corneal scarring.

Pub. Date : 2012 Jan

PMID : 22178289






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Both electrophilic PPARgamma ligands (CDDO-Me and 15d-PGJ(2)) potently inhibited TGFbeta-induced myofibroblast differentiation, but PPARgamma was only partially required for inhibition of myofibroblast differentiation by either agent. 15d-pgj transforming growth factor beta 1 Homo sapiens
2 CDDO-Me and 15d-PGJ(2) are strong inhibitors of TGFbeta-induced corneal fibroblast to myofibroblast differentiation in vitro, suggesting this class of agents as potential novel therapies for corneal scarring warranting further study in pre-clinical animal models. 15d-pgj transforming growth factor beta 1 Homo sapiens