Pub. Date : 2012 Jan 6
PMID : 22177954
14 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Oleanane triterpenoid CDDO-Me inhibits Akt activity without affecting PDK1 kinase or PP2A phosphatase activity in cancer cells. | bardoxolone methyl | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Our previous studies have shown that methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate (CDDO-Me), a oleanane synthetic triterpenoid induces apoptosis in prostate cancer cells by inhibiting the Akt/NF-kappaB/mTOR signaling cascade; however, the mechanism by which CDDO-Me inhibits Akt/NF-kappaB/mTOR signaling has remained undetermined. | bardoxolone methyl | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Our previous studies have shown that methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate (CDDO-Me), a oleanane synthetic triterpenoid induces apoptosis in prostate cancer cells by inhibiting the Akt/NF-kappaB/mTOR signaling cascade; however, the mechanism by which CDDO-Me inhibits Akt/NF-kappaB/mTOR signaling has remained undetermined. | bardoxolone methyl | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Present studies show that Akt plays a critical role in the response of prostate cancer cells to CDDO-Me. | bardoxolone methyl | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | Silencing of Akt sensitized PC-3 cells to CDDO-Me, whereas its overexpression rendered them resistant to CDDO-Me. | bardoxolone methyl | AKT serine/threonine kinase 1 | Homo sapiens |
| 6 | Evaluation of the effect of CDDO-Me on Akt which lies upstream of NF-kappaB and mTOR showed that CDDO-Me directly inhibits the Akt kinase activity in cell-free kinase activity assay and in vivo without modulating the activity of PDK1, the upstream kinase that phosphorylates and activates Akt. | bardoxolone methyl | AKT serine/threonine kinase 1 | Homo sapiens |
| 7 | Evaluation of the effect of CDDO-Me on Akt which lies upstream of NF-kappaB and mTOR showed that CDDO-Me directly inhibits the Akt kinase activity in cell-free kinase activity assay and in vivo without modulating the activity of PDK1, the upstream kinase that phosphorylates and activates Akt. | bardoxolone methyl | AKT serine/threonine kinase 1 | Homo sapiens |
| 8 | Evaluation of the effect of CDDO-Me on Akt which lies upstream of NF-kappaB and mTOR showed that CDDO-Me directly inhibits the Akt kinase activity in cell-free kinase activity assay and in vivo without modulating the activity of PDK1, the upstream kinase that phosphorylates and activates Akt. | bardoxolone methyl | AKT serine/threonine kinase 1 | Homo sapiens |
| 9 | Evaluation of the effect of CDDO-Me on Akt which lies upstream of NF-kappaB and mTOR showed that CDDO-Me directly inhibits the Akt kinase activity in cell-free kinase activity assay and in vivo without modulating the activity of PDK1, the upstream kinase that phosphorylates and activates Akt. | bardoxolone methyl | AKT serine/threonine kinase 1 | Homo sapiens |
| 10 | Evaluation of the effect of CDDO-Me on Akt which lies upstream of NF-kappaB and mTOR showed that CDDO-Me directly inhibits the Akt kinase activity in cell-free kinase activity assay and in vivo without modulating the activity of PDK1, the upstream kinase that phosphorylates and activates Akt. | bardoxolone methyl | AKT serine/threonine kinase 1 | Homo sapiens |
| 11 | Evaluation of the effect of CDDO-Me on Akt which lies upstream of NF-kappaB and mTOR showed that CDDO-Me directly inhibits the Akt kinase activity in cell-free kinase activity assay and in vivo without modulating the activity of PDK1, the upstream kinase that phosphorylates and activates Akt. | bardoxolone methyl | AKT serine/threonine kinase 1 | Homo sapiens |
| 12 | Further, inhibition of p-Akt by CDDO-Me was not attributable to an increase in the activity of protein phosphatase 2A (PP2A) or PH domain/leucine-rich repeat protein phosphatase1 (PHLPP1) both of which dephosphorylate p-Akt. | bardoxolone methyl | AKT serine/threonine kinase 1 | Homo sapiens |
| 13 | These findings show that Akt is a direct target of CDDO-Me in the Akt/NF-kappaB/mTOR prosurvival signaling axis. | bardoxolone methyl | AKT serine/threonine kinase 1 | Homo sapiens |
| 14 | These findings show that Akt is a direct target of CDDO-Me in the Akt/NF-kappaB/mTOR prosurvival signaling axis. | bardoxolone methyl | AKT serine/threonine kinase 1 | Homo sapiens |