Title : Modulation of aldehyde dehydrogenase activity affects (±)-4-hydroxy-2E-nonenal (HNE) toxicity and HNE-protein adduct levels in PC12 cells.

Pub. Date : 2012 Jul

PMID : 22170038






1 Functional Relationships(s)
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1 We sought to first establish the role of ALDH1A1 in mediating HNE toxicity in PC12 cells by overexpressing ALDH1A1 and by using disulfiram, an ALDH inhibitor. Disulfiram aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus