Title : Activation of IL-11/STAT3 pathway in preconditioned human skeletal myoblasts blocks apoptotic cascade under oxidant stress.

Pub. Date : 2012 Jan

PMID : 22168497






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1 The cytoprotective effect of diazoxide preconditioning was blocked by Erk1/2 inhibitor PD98059 (20-100 microM), which abrogated STAT-3 phosphorylation, thus confirming a possible involvement of Erk1/2/STAT3 signaling downstream of IL-11 in cell survival. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one interleukin 11 Homo sapiens