Title : Induction of heme oxygenase-1 by Macleaya cordata extract and its constituent sanguinarine in RAW264.7 cells.

Pub. Date : 2012 Mar

PMID : 22166397






2 Functional Relationships(s)
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1 Sanguinarine-induced Hmox1 mRNA expression was suppressed by SB203580, a pharmacologic inhibitor of p38 mitogen-activated protein kinases (p38 MAPKs). sanguinarine mitogen-activated protein kinase 14 Mus musculus
2 We conclude that sanguinarine may, under appropriate conditions, increase the capacity of the enzymatic antioxidant defence system via activation of the p38 MAPK/Nrf2 pathway. sanguinarine mitogen-activated protein kinase 14 Mus musculus