Title : Inhibition of microRNA-17 improves lung and heart function in experimental pulmonary hypertension.

Pub. Date : 2012 Feb 15

PMID : 22161164






1 Functional Relationships(s)
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1 In the monocrotaline-induced PH rat model, A-17 treatment significantly decreased right ventricular systolic pressure and total pulmonary vascular resistance index, increased pulmonary artery acceleration time, normalized cardiac output, and decreased pulmonary vascular remodeling. Monocrotaline immunoglobulin kappa variable 2-30 Homo sapiens