Title : R(+)-, Rac-, and S(-)-bupivacaine stereostructure-specifically interact with membrane lipids at cardiotoxically relevant concentrations.

Pub. Date : 2012 Feb

PMID : 22156330






1 Functional Relationships(s)
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1 Bupivacaine interacted with the membranes at cardiotoxic 5 muM with the potency being S(-)-enantiomer < racemate < R(+)-enantiomer, which agreed with the rank order of their cardiotoxicity. Bupivacaine latexin Homo sapiens