Pub. Date : 2012 Jan
PMID : 22156195
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients. | Temozolomide | N-methylpurine DNA glycosylase | Homo sapiens |
| 2 | Here, we investigated our hypothesis that the base excision repair enzyme alkylpurine-DNA-N-glycosylase (APNG), which repairs the cytotoxic lesions N3-methyladenine and N7-methylguanine, may contribute to TMZ resistance. | Temozolomide | N-methylpurine DNA glycosylase | Homo sapiens |
| 3 | Here, we investigated our hypothesis that the base excision repair enzyme alkylpurine-DNA-N-glycosylase (APNG), which repairs the cytotoxic lesions N3-methyladenine and N7-methylguanine, may contribute to TMZ resistance. | Temozolomide | N-methylpurine DNA glycosylase | Homo sapiens |
| 4 | Silencing of APNG in established and primary TMZ-resistant GBM cell lines endogenously expressing MGMT and APNG attenuated repair of TMZ-induced DNA damage and enhanced apoptosis. | Temozolomide | N-methylpurine DNA glycosylase | Homo sapiens |
| 5 | Silencing of APNG in established and primary TMZ-resistant GBM cell lines endogenously expressing MGMT and APNG attenuated repair of TMZ-induced DNA damage and enhanced apoptosis. | Temozolomide | N-methylpurine DNA glycosylase | Homo sapiens |
| 6 | Silencing of APNG in established and primary TMZ-resistant GBM cell lines endogenously expressing MGMT and APNG attenuated repair of TMZ-induced DNA damage and enhanced apoptosis. | Temozolomide | N-methylpurine DNA glycosylase | Homo sapiens |
| 7 | Collectively, our data demonstrate that APNG contributes to TMZ resistance in GBM and may be useful in the diagnosis and treatment of the disease. | Temozolomide | N-methylpurine DNA glycosylase | Homo sapiens |