Pub. Date : 2012 Feb 6
PMID : 22146149
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this report, we show that treatment of HepG2 cells with endosulfan significantly increased oxidative stress-responsive transcription via AP-1 activation. | Endosulfan | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 2 | Endosulfan exposure also caused an increase in c-Jun phosphorylation. | Endosulfan | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 3 | These results suggest a model for endosulfan toxicity in which endosulfan increases ERK1/2 and p38 activities and these activated MAPKs then increase c-Jun phosphorylation. | Endosulfan | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |