Title : MEK1/2 inhibitor selumetinib (AZD6244) inhibits growth of ovarian clear cell carcinoma in a PEA-15-dependent manner in a mouse xenograft model.

Pub. Date : 2012 Feb

PMID : 22144664






1 Functional Relationships(s)
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1 Our findings indicate that the MEK-ERK pathway is a potential target for EGFR-overexpressing CCC and indicate that selumetinib and erlotinib are worth exploring as therapeutic agents for CCC. AZD 6244 mitogen-activated protein kinase 1 Mus musculus