Title : Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function.

Pub. Date : 2011 Dec 20

PMID : 22143799






2 Functional Relationships(s)
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1 Skeletal muscle-specific inactivation of mTORC1 in mice results in smaller muscle fibers, fewer mitochondria, increased glycogen stores, and a progressive myopathy that causes premature death. Glycogen CREB regulated transcription coactivator 1 Mus musculus
2 In addition, we find that mTORC1 has a much stronger effect than PGC-1alpha on the glycogen content in muscle. Glycogen CREB regulated transcription coactivator 1 Mus musculus