Title : Glycine reuptake inhibitor RG1678: a pharmacologic characterization of an investigational agent for the treatment of schizophrenia.

Pub. Date : 2012 Feb

PMID : 22138164






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 It is thought that this abnormal functioning can be corrected by increasing availability of the NMDA co-agonist glycine through inhibition of glycine transporter type 1 (GlyT1). Glycine solute carrier family 6 member 9 Homo sapiens
2 It is thought that this abnormal functioning can be corrected by increasing availability of the NMDA co-agonist glycine through inhibition of glycine transporter type 1 (GlyT1). Glycine solute carrier family 6 member 9 Homo sapiens
3 In vitro, RG1678 noncompetitively inhibited glycine uptake at human GlyT1 with a concentration exhibiting half-maximal inhibition (IC(50)) of 25 nM and competitively blocked [(3)H]ORG24598 binding sites at human GlyT1b in membranes from Chinese hamster ovary cells. Glycine solute carrier family 6 member 9 Homo sapiens