Title : Lycopene and the LXRα agonist T0901317 synergistically inhibit the proliferation of androgen-independent prostate cancer cells via the PPARγ-LXRα-ABCA1 pathway.

Pub. Date : 2012 Sep

PMID : 22137263






1 Functional Relationships(s)
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1 Lycopene (10 muM) in the presence of a specific antagonist of PPARgamma (GW9662) or of LXRalpha (GGPP) restored the proliferation of DU145 cells and significantly suppressed lycopene-induced protein and mRNA expression of PPARgamma and LXRalpha and cholesterol efflux. Cholesterol nuclear receptor subfamily 1 group H member 3 Homo sapiens