Title : Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice.

Pub. Date : 2012 Jan 20

PMID : 22128176

1 Functional Relationships(s)
Compound Name
Protein Name
1 Despite JNK activation, XBP1Delta displayed increased hepatic insulin sensitivity during hyperinsulinemic-euglycemic clamp studies, which was associated with increased insulin-stimulated IRS2 tyrosine phosphorylation, reduced hepatic DAG content, and reduced PKCepsilon activity. Tyrosine X-box binding protein 1 Mus musculus