Title : Amer2 protein is a novel negative regulator of Wnt/β-catenin signaling involved in neuroectodermal patterning.

Pub. Date : 2012 Jan 13

PMID : 22128170






1 Functional Relationships(s)
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1 Here, we show that Amer2 recruits APC to the plasma membrane by binding to phosphatidylinositol 4,5-bisphosphate lipids via lysine-rich motifs and that APC links beta-catenin and the destruction complex components axin and conductin to Amer2. phosphatidylinositol 4,5-bisphosphate lipids APC membrane recruitment protein 2 S homeolog Xenopus laevis