Title : Mechanisms of allosteric gene regulation by NMR quantification of microsecond-millisecond protein dynamics.

Pub. Date : 2012 Jan 13

PMID : 22115774






5 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 The trp RNA-binding attenuation protein (TRAP) is a paradigmatic allosteric protein that regulates the tryptophan biosynthetic genes associated with the trp operon in bacilli. Tryptophan TRAP Homo sapiens
2 The trp RNA-binding attenuation protein (TRAP) is a paradigmatic allosteric protein that regulates the tryptophan biosynthetic genes associated with the trp operon in bacilli. Tryptophan TRAP Homo sapiens
3 The ring-shaped 11-mer TRAP is activated for recognition of a specific trp-mRNA target by binding up to 11 tryptophan molecules. Tryptophan TRAP Homo sapiens
4 To characterize the mechanisms of tryptophan-induced TRAP activation, we have performed methyl relaxation dispersion (MRD) nuclear magnetic resonance (NMR) experiments that probe the time-dependent structure of TRAP in the microsecond-to-millisecond "chemical exchange" time window. Tryptophan TRAP Homo sapiens
5 To characterize the mechanisms of tryptophan-induced TRAP activation, we have performed methyl relaxation dispersion (MRD) nuclear magnetic resonance (NMR) experiments that probe the time-dependent structure of TRAP in the microsecond-to-millisecond "chemical exchange" time window. Tryptophan TRAP Homo sapiens