Title : Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels.

Pub. Date : 2012 Jan 1

PMID : 22100703






2 Functional Relationships(s)
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1 Using NMR chemical shift mapping, we show that the important binding residues in FKBP12 are located in its hydrophobic FK506 binding region. Tacrolimus FKBP prolyl isomerase 1A pseudogene 3 Homo sapiens
2 Consistently, we demonstrate that FK506 can competitively inhibit the interaction between FKBP12 and the dipeptide motifs of the calcium channels. Tacrolimus FKBP prolyl isomerase 1A pseudogene 3 Homo sapiens