Title : Inhibition of IGF-1 signaling by genistein: modulation of E-cadherin expression and downregulation of β-catenin signaling in hormone refractory PC-3 prostate cancer cells.

Pub. Date : 2012

PMID : 22098108






1 Functional Relationships(s)
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1 In IGF-1-treated cells, genistein effectively inhibited the phosphorylation of IGF-1R and the phosphorylation of its downstream targets, such as Src, Akt, and glycogen synthase kinase-3beta (GSk-3beta). Genistein AKT serine/threonine kinase 1 Homo sapiens