Title : Nkx3.2-induced suppression of Runx2 is a crucial mediator of hypoxia-dependent maintenance of chondrocyte phenotypes.

Pub. Date : 2011 Dec 9

PMID : 22093831






3 Functional Relationships(s)
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1 Over-expression of exogenous Nkx3.2 promoted glycosaminoglycan (GAG) production and inhibited Runx2 mRNA expression and, based on a dual luciferase assay, Runx2 promoter activity. Glycosaminoglycans NK3 homeobox 2 Mus musculus
2 Over-expression of exogenous Nkx3.2 promoted glycosaminoglycan (GAG) production and inhibited Runx2 mRNA expression and, based on a dual luciferase assay, Runx2 promoter activity. Glycosaminoglycans NK3 homeobox 2 Mus musculus
3 Interestingly, downregulation of Nkx3.2 using RNAi abolished hypoxia-dependent GAG production and restored Runx2 mRNA expression and promoter activity. Glycosaminoglycans NK3 homeobox 2 Mus musculus