Title : Hypoxia and hypoxia mimetics inhibit TNF-dependent VCAM1 induction in the 5A32 endothelial cell line via a hypoxia inducible factor dependent mechanism.

Pub. Date : 2012 Feb

PMID : 22093255






3 Functional Relationships(s)
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1 BACKGROUND: We previously reported that iron chelators inhibit TNFalpha-mediated induction of VCAM-1 in human dermal microvascular endothelial cells. Iron tumor necrosis factor Homo sapiens
2 RESULTS: Hypoxia and the non-iron binding hypoxia mimetic dimethyl oxallyl glycine (DMOG) inhibited TNFalpha-mediated induction of VCAM-1. Iron tumor necrosis factor Homo sapiens
3 CONCLUSION: Iron chelators, non-metal binding hypoxia mimetics, and hypoxia all inhibit TNFalpha-mediated VCAM-1 expression. Iron tumor necrosis factor Homo sapiens