Title : Plasma protein binding of sorafenib, a multi kinase inhibitor: in vitro and in cancer patients.

Pub. Date : 2012 Dec

PMID : 22089297






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In isolated protein solutions, 99.8% and 79.3% of sorafenib was bound to human serum albumin (HSA) (4 g/dL) and alpha(1)-acid glycoprotein (AAG) (0.1 g/dL) with binding constants of 1.24 x 10(6) M(-1) and 1.40 x 10(5) M(-1), respectively. Sorafenib albumin Homo sapiens