Title : Dual mTORC1/mTORC2 inhibition diminishes Akt activation and induces Puma-dependent apoptosis in lymphoid malignancies.

Pub. Date : 2012 Jan 12

PMID : 22080480






1 Functional Relationships(s)
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1 Moreover, OSI-027 inhibited phosphorylation of mTORC1 and mTORC2 substrates, up-regulated Puma, and induced regressions in Jeko xenografts. OSI 027 CREB regulated transcription coactivator 1 Mus musculus