Title : The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors.

Pub. Date : 2012 Jan 1

PMID : 22079761






2 Functional Relationships(s)
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1 Novel prolylcarboxypeptidase (PrCP) inhibitors with nanomolar IC(50) values were prepared by replacing the previously described dichlorobenzimidazole-substituted pyrrolidine amides with a variety of substituted benzylamine amides. dichlorobenzimidazole-substituted pyrrolidine amides prolylcarboxypeptidase (angiotensinase C) Mus musculus
2 Novel prolylcarboxypeptidase (PrCP) inhibitors with nanomolar IC(50) values were prepared by replacing the previously described dichlorobenzimidazole-substituted pyrrolidine amides with a variety of substituted benzylamine amides. dichlorobenzimidazole-substituted pyrrolidine amides prolylcarboxypeptidase (angiotensinase C) Mus musculus