Title : Dual inhibition of (V600E)BRAF and the PI3K/AKT/mTOR pathway cooperates to induce apoptosis in melanoma cells through a MEK-independent mechanism.

Pub. Date : 2012 Jan 28

PMID : 22056813






1 Functional Relationships(s)
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1 Here, we show that BRAF depletion by siRNA or inhibition of its activity by treatment with RAF inhibitor Sorafenib induces apoptosis in NPA melanoma cells expressing oncogenic (V600E)BRAF. Sorafenib zinc fingers and homeoboxes 2 Homo sapiens