Title : Exposure to cadmium chloride influences astrocyte-elevated gene-1 (AEG-1) expression in MDA-MB231 human breast cancer cells.

Pub. Date : 2012 Jan

PMID : 22041583






1 Functional Relationships(s)
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1 In addition, due to the acknowledged role of AEG-1 in the intranuclear shuttling of NF-kappaB p65 subunit, we also showed that CdCl(2) treatment determines the decrease of p65 amount in nuclear extracts and the down-regulation of the NF-kappaB downstream genes c-fos and c-jun, thus providing a new contribution to the comprehension of the intracellular molecular mechanisms implicated in Cd-breast cancer cell interactions. cdcl Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens