Title : Anti-neutrophilic inflammatory activity of ASP3258, a novel phosphodiesterase type 4 inhibitor.

Pub. Date : 2012 Jan

PMID : 22041526






1 Functional Relationships(s)
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1 In in vitro experiments using human peripheral blood neutrophils, PDE4 inhibitors ASP3258, cilomilast, and roflumilast inhibited fMLP-induced superoxide production in a concentration-dependent manner with IC50 values of 5.0, 96, and 4.7 nM, respectively. Superoxides formyl peptide receptor 1 Homo sapiens