Title : Virtual mutagenesis of isocitrate dehydrogenase 1 involved in glioblastoma multiforme.

Pub. Date : 2011 Sep

PMID : 22040412






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 IDH1 changes of binding free energy (DeltaE) suggested that the A132Arg residue from chain A contributes three hydrogen bonds to the ICT alpha-carboxyl and beta-carboxyl groups, while the other nine residues involved in ICT binding form only one or two hydrogen bonds. Hydrogen isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens
2 IDH1 changes of binding free energy (DeltaE) suggested that the A132Arg residue from chain A contributes three hydrogen bonds to the ICT alpha-carboxyl and beta-carboxyl groups, while the other nine residues involved in ICT binding form only one or two hydrogen bonds. Hydrogen isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens