Title : Pitavastatin, a new HMG-CoA reductase inhibitor, induces phototoxicity in human keratinocytes NCTC-2544 through the formation of benzophenanthridine-like photoproducts.

Pub. Date : 2012 Mar

PMID : 22038141






1 Functional Relationships(s)
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1 Flow cytometric analysis indicated that pitavastatin and the photoproduct PP4 principally induced necrosis, as revealed by the large appearance of propidium iodide-positive cells and also confirmed by the rapid drop in cellular ATP levels. Propidium protein phosphatase 4 catalytic subunit Homo sapiens