Title : Inhibiting PI3K reduces mammary tumor growth and induces hyperglycemia in a mouse model of insulin resistance and hyperinsulinemia.

Pub. Date : 2012 Jul 5

PMID : 22037215






2 Functional Relationships(s)
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1 NVP-BKM120 treatment decreased phosphorylation of Akt and S6 ribosomal protein (S6rp); no change in Erk1/2 phosphorylation was seen. NVP-BKM120 thymoma viral proto-oncogene 1 Mus musculus
2 Overall, the results of this study demonstrated that inhibiting PI3K/Akt/mTOR signaling with the oral agents NVP-BKM120 and NVP-BEZ235 decreased mammary tumor growth in the hyperinsulinemic MKR mouse. NVP-BKM120 thymoma viral proto-oncogene 1 Mus musculus