Title : Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3.

Pub. Date : 2011 Sep 14

PMID : 22025881






1 Functional Relationships(s)
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1 RESULTS: Sorafenib decreased STAT3 phosphorylation at the tyrosine and serine residues (Y705 and S727), but did not affect Janus kinase 2 (JAK2) and phospha-tase shatterproof 2 (SHP2), which is associated with growth inhibition in HCC cells. Tyrosine signal transducer and activator of transcription 3 Rattus norvegicus