Title : The antifungal drug itraconazole inhibits vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells.

Pub. Date : 2011 Dec 23

PMID : 22025615






3 Functional Relationships(s)
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1 We report here that itraconazole significantly inhibited the binding of vascular endothelial growth factor (VEGF) to VEGF receptor 2 (VEGFR2) and that both VEGFR2 and an immediate downstream substrate, phospholipase C gamma1, failed to become activated after VEGF stimulation. Itraconazole vascular endothelial growth factor A Homo sapiens
2 We report here that itraconazole significantly inhibited the binding of vascular endothelial growth factor (VEGF) to VEGF receptor 2 (VEGFR2) and that both VEGFR2 and an immediate downstream substrate, phospholipase C gamma1, failed to become activated after VEGF stimulation. Itraconazole vascular endothelial growth factor A Homo sapiens
3 We report here that itraconazole significantly inhibited the binding of vascular endothelial growth factor (VEGF) to VEGF receptor 2 (VEGFR2) and that both VEGFR2 and an immediate downstream substrate, phospholipase C gamma1, failed to become activated after VEGF stimulation. Itraconazole vascular endothelial growth factor A Homo sapiens