Title : Cdk1/cyclin B plays a key role in mitotic arrest-induced apoptosis by phosphorylation of Mcl-1, promoting its degradation and freeing Bak from sequestration.

Pub. Date : 2012 Jan 15

PMID : 22024133






1 Functional Relationships(s)
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Protein Name
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1 Vinblastine treatment caused degradation of Mcl-1 in cells in which apoptosis was blocked by Bcl-xL overexpression, indicating that Mcl-1 degradation was not a consequence of apoptosis. Vinblastine BCL2 like 1 Homo sapiens