Title : Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans.

Pub. Date : 2011 Nov

PMID : 22023369






2 Functional Relationships(s)
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1 Removal of the fucose residue from the N-glycans of the Fc portion of immunoglobulin G (IgG) results in a dramatic enhancement of antibody-dependent cellular cytotoxicity (ADCC) through improved affinity for Fcgamma receptor IIIa (FcgammaRIIIa). n-glycans Fc gamma receptor IIIa Homo sapiens
2 Removal of the fucose residue from the N-glycans of the Fc portion of immunoglobulin G (IgG) results in a dramatic enhancement of antibody-dependent cellular cytotoxicity (ADCC) through improved affinity for Fcgamma receptor IIIa (FcgammaRIIIa). n-glycans Fc gamma receptor IIIa Homo sapiens